TOTIPHARMACEUTICALS

Products in development

Theriosol antimicrobial “niosome” based nanotherapeutic as antibiotic replacer

Tackling ANTIBIOTIC RESISTANCE

Replace current antibiotic prophylaxis and therapy by natural antimicrobials that does not generate antibiotic resistance in 3 main nosocomial human pathogens: Acinetobacter Baumannii, Staphylococcus aureus, Pseudomonas aeruginosa

Biocidal (G+ & G-) and fungicidal on more than 250 pathogens

no perturbation on microflora in the GI tract of mammals (in vitro test on mices)

  • IV and IP routes under preclinical tests (sepsis murine model with Acinetobacter baumannii)
  • Improved efficiency of “soft niosome” versus lipid micelles or double micellar capsules
  • Development of enteral route with better plasma profile than classical oral route

Artificial insemination

THERIOSOL as antibiotic replacer

Nano-polypharmacology

We are combining nanotechnology with polypharmacology with a constant focus on synergism at different levels.

 

We are able to modify the way commercial antibiotics are delivered to pathogens membranes and thus to extent their scope of susceptibility.

We can make Vancomycin (approved for treating gram-positive bacteria) biocidal towards G- bacteria

We have discovered highly potent new spermicides with a new mode of action:

THERIOCIDE is in early pre-development phase for use in mammals

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